Showing posts with label chemosensation. Show all posts
Showing posts with label chemosensation. Show all posts

Thursday, November 3, 2022

Chemical Intelligence


'E-nose' sniffs out mixtures of volatile organic compounds
Jun 2022, phys.org

Electric nose with porous metal-organic framework films that distinguish xylene isomer mixtures for environmental health monitoring.

Previously, researchers used gas chromatography analysis to identify the three forms of xylene. But this procedure requires large instruments that are expensive, and the analyses are time intensive. 

The researchers prepared six different porous MOF films known to adsorb xylene isomers and applied them to gravimetric sensors in an array called an "e-nose." By analyzing the sensor array data with a machine learning algorithm, the team could determine the composition of the mixtures with 86% accuracy for the 10-ppm mixture and 96% accuracy for the 100-ppm mixture

via Karlsruhe Institute of Technology's Institute of Functional Interfaces and University of Pittsburgh Department of Chemical & Petroleum Engineering: VOC Mixture Sensing with a MOF Film Sensor Array: Detection and Discrimination of Xylene Isomers and Their Ternary Blends, ACS Sensors (2022). DOI: 10.1021/acssensors.2c00301

a detailed blueprint of god, top - secret document 


Nano-sensor detects pesticides on fruit in minutes
Jun 2022, phys.org

Current techniques for detecting pesticides on single products before consumption are restricted in practice by the high cost and cumbersome manufacturing of its sensors.

Uses flame-sprayed nanoparticles made from silver to increase the signal of chemicals, "The flame spray can be used to quickly produce uniform surface-enhanced Raman scattering (SERS) films across large areas, removing one of the key barriers to scalability,"

To test the sensors' practical application, the researchers calibrated them to detect low concentrations of parathion-ethyl, a toxic agricultural insecticide that is banned or restricted in most countries. A small amount of parathion-ethyl was placed on part of an apple. The residues were later collected with a cotton swab that was immersed in a solution to dissolve the pesticide molecules. The solution was dropped on the sensor, which confirmed the presence of pesticides.

via Karolinska Institutet: SERS Hotspot Engineering by Aerosol Self-Assembly of Plasmonic Ag Nanoaggregates with Tunable Interparticle Distance, Advanced Science (2022). DOI: 10.1002/advs.202201133


Damaged plants and fake perfumes can be identified rapidly and reliably in real time
Jun 2022, phys.org

Chiral detection:

Most natural chiral substances are found in two mirror-image forms present in different relative quantities. Therefore, every plant and every perfume must have its own individual chiral signature.

The relative ratios of the two enantiomers of pinene naturally vary in the emissions of such plants, but critically depend on the state of health of the plant.

Fake perfumes will have a chiral signature that differs from that of the originals.

The Mainz-based researchers have developed a cavity-enhanced polarimetric method for optical chiral analysis to detect the differing optical rotation effects of chiral molecules under polarized light. The researchers have been able to achieve a sensitivity that is better than that of the current state-of-the-art equipment by several orders of magnitude.

via Universitaet Mainz and the Max Planck Institute for Chemistry: Lykourgos Bougas et al, Absolute optical chiral analysis using cavity-enhanced polarimetry, Science Advances (2022). DOI: 10.1126/sciadv.abm3749

 

Monday, May 9, 2022

Ant Ink and Infotaxis


The ant secretion methyl-4-methyl-pyrrole-2-carboxylate - "innocuous, faintly grassy, sulphurous, or fruitlike with a hint of naphtha", "an ichor of extraordinary power for the ants.

"They sweep their antennae back and forth in advance of the head to catch the odorant molecules. When a forager takes a long turn to the left and starts to run away from the track, its left antenna break out of the odor space first and is no longer stimulated by the guiding substance. In a few thousandths of a second, the any perceives the change and pulls back to the right." (p30-31) 

Biophilia: The Human Bond with Other Species 
E. O. Wilson, Harvard University Press, 1984

Tuesday, August 10, 2021

Headline Party

My first master's degree was in architecture, and I graduated the day the United States housing market collapsed. So my second master's was in public health, and I got my first job the day Planet Earth went into pandemic lockdown. Expertise in indoor air quality and occupant exposure during an airborne pandemic will make your life pretty busy. Hence, a list of smell-related headlines I've been collecting in the meantime:

Unparalleled inventory of the human gut ecosystem
Jul 2020, phys.org
The Unified Human Gastrointestinal Genome (UHGG) collection, comprising 204,938 nonredundant genomes from 4,644 gut prokaryotes. These genomes encode >170 million protein sequences, which we collated in the Unified Human Gastrointestinal Protein (UHGP) catalog. 

via the European Bioinformatics Institute: Alexandre Almeida et al. A unified catalog of 204,938 reference genomes from the human gut microbiome, Nature Biotechnology (2020). DOI: 10.1038/s41587-020-0603-3
Fresh sea spray turns 'sour' after being airborne
Jan 2021, phys.org
"The smallest particles become 100,000 times more acidic than the ocean within two minutes," said Angle, first author of the paper.

via University of California San Diego: Kyle J. Angle et al. Acidity across the interface from the ocean surface to sea spray aerosol, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.2018397118
Researchers create a highly sensitive biohybrid olfactory sensor
Jan 2021, phys.org
So we decided to combine existing biological sensors directly with artificial systems to create highly sensitive volatile organic compound (VOC) sensors. We call these biohybrid sensors."

Takeuchi and his team essentially grafted a set of olfactory receptors from an insect into a device that feeds certain odors to the receptors and also reads how the receptors respond to these odors. 

via the University of Tokyo: T. Yamada el al. Highly sensitive VOC detectors using insect olfactory receptors reconstituted into lipid bilayers. Science Advances (2021). DOI: 10.1126/sciadv.abd2013
Male butterflies mark their mates with repulsive smell during sex to 'turn off' other suitors
Jan 2021, phys.org

Butterfly genitals secrete an odor that covers female genitals, deterring other males from mating with them. Occimene - it's the anti-aphrodisiac (for moths).

via University of Cambridge: Darragh K, Orteu A, Black D, Byers KJRP, Szczerbowski D, Warren IA, et al. (2021) A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between closely related Heliconius butterflies. PLoS Biol 19(1): e3001022. 


Cosmic mouthful - Tasters savor fine wine that orbited Earth
Mar 2021, phys.org
This comes via the Institute for Wine and Vine Research in Bordeaux, and of course the International Space Station.
Researchers develop new smell test for Parkinson's, Alzheimer's and COVID-19
May 2021, phys.org
A new smell test developed by Queen Mary University of London researchers has been found to be easy to use in patients with Parkinson's disease, and could also be helpful in diagnosing COVID-19 in the broader population.

via  Queen Mary, University of London: A. Said Ismail et al. A novel capsule-based smell test fabricated via coaxial dripping, Journal of The Royal Society Interface (2021). DOI: 10.1098/rsif.2021.0039
Scientists invent an artificial nose for continuous bacterial monitoring
Jun 2021, phys.org
via Americans for Ben-Gurion University: Nitzan Shauloff et al, Sniffing Bacteria with a Carbon-Dot Artificial Nose, Nano-Micro Letters (2021). DOI: 10.1007/s40820-021-00610-w

Thursday, March 4, 2021

Artificial Pheromones and Biomimetic Mind Control


Breathing may change your mind about free will
Feb 2020, phy.org

This reminds us how interconnected the olfactory system is with our body. "Osmetic Ontogenesis" by Hosek and Freeman in 2001 is a great dive into this subject, with a title that's hard to forget.
Scientists at EPFL in Switzerland have shown that you are more likely to initiate a voluntary decision as you exhale. 
via by Ecole Polytechnique Federale de Lausanne: Hyeong-Dong Park et al. Breathing is coupled with voluntary action and the cortical readiness potential, Nature Communications (2020). DOI: 10.1038/s41467-019-13967-9



Gut bacteria may modify behavior in worms, influencing eating habits
Jun 2020, phys.org
Specific gut bacteria in the worm may modify the animal's behavior, directing its dining decisions.

"In this way, the bacteria can take control over the host animal's sensory decision-making process, which affects their responses to odors and may influence food choices" said Dr. Sengupta.
via the National Institutes of Health: MP O'Donnell et al. Modulation of olfactory behavior by a gut bacteria-produced neurotransmitter. Nature, 2020. DOI: 10.1038/s41586-020-2395-5


Non-invasive nerve stimulation boosts learning of foreign language sounds
Aug 2020, phys.org

Can this be used for olfactory nerves as well?
Researchers significantly improved the ability of native English speakers to distinguish between Mandarin tones by using precisely timed, non-invasive stimulation of the vagus nerve.
via University of Pittsburg: Non-invasive peripheral nerve stimulation selectively enhances speech category learning in adults. Fernando Llanos et al. npj [Nature Partner Journal] Science of Learning volume 5, Article number: 12 (2020). https://www.nature.com/articles/s41539-020-0070-0


A lab that reads—and writes—our dreams
Apr 2020, phys.org

Well-known olfactory researcher Judith Amoore dispenses odors as subjects slip into sleep. In follow-up interviews, subjects report memories associated with the smells.

The device is supposed to trigger scents with positive associations during nightmares to help trauma and PTSD sufferers without them even being awake.

via MIT and the Dormio device

Augmented Reality, EPFL École polytechnique fédérale de Lausanne

Pregnancy test for water' delivers fast, easy results on water quality
Jul 2020, phys.org

Frankenstein as f***
In cell-free synthetic biology, researchers take the molecular machinery—including DNA, RNA and proteins—out of cells, and then reprogram that machinery to perform new tasks. The idea is akin to opening the hood of the car and removing the engine, which allows researchers to use the engine for different purposes, free from the constraints of the car. In this case, Lucks' team used molecular machinery from bacterial cells.

"We found out how bacteria naturally taste things in their water," Lucks added. "They do so with little molecular-level 'taste buds'. Cell-free synthetic biology allows us to take those little molecular taste buds out and put them into a test tube. We can then 're-wire' them up to produce a visual signal. It glows to let the user quickly and easily see if there's a contaminant in their water."

These reprogramed "taste buds" are freeze-dried to become shelf-stable and put into test tubes. Adding a drop of water to the tube—and then flicking it—sets off a chemical reaction that causes the freeze-dried pellet to glow in the presence of a contaminant.

In Paradise, California, after the recent wildfire disaster there, ... their teams tested ROSALIND alongside gold-standard water tests and discovered that ROSALIND was able to identify the presence of elevated toxic metals in the water supply. It also provided much faster and less expensive results.
via Northwestern University: Cell-free biosensors for rapid detection of water contaminants, Nature Biotechnology (2020). DOI: 10.1038/s41587-020-0571-7


Exhaled biomarkers can reveal lung disease
Jul 2020, phys.org

Inhalable nanosensors:
"We envision that this technology would allow you to inhale a sensor and then breathe out a volatile gas in about 10 minutes that reports on the status of your lungs and whether the medicines you are taking are working," says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT.
via Massachusetts Institute of Technology: Chan, L.W., Anahtar, M.N., Ong, T. et al. Engineering synthetic breath biomarkers for respiratory disease, Nature Nanotechnology (2020). DOI: 10.1038/s41565-020-0723-4


Researchers develop sensors that detect human biomarkers and toxic gas
Nov 2020, phys.org

VOCs are going to be the new big data treasure chest.

via Penn State: Ning Yi et al. Stretchable gas sensors for detecting biomarkers from humans and exposed environments, TrAC Trends in Analytical Chemistry (2020). DOI: 10.1016/j.trac.2020.116085


AI-powered 'electronic nose' to sniff out meat freshness
Nov 2020, phys.org

Go figure it has to see it to smell it...
The e-nose developed by NTU scientists and their collaborators comprises two elements: a colored barcode that reacts with gasses produced by decaying meat; and a barcode reader that uses AI to interpret the combination of colors on the barcode. To make the e-nose portable, the scientists integrated it into a smartphone app that can yield results in 30 seconds.
via Nanyang Technological University: Lingling Guo et al. Portable Food‐Freshness Prediction Platform Based on Colorimetric Barcode Combinatorics and Deep Convolutional Neural Networks, Advanced Materials (2020). DOI: 10.1002/adma.202004805

The Cat Copter, for real.

A system for swarm robotics applications inspired by pheromone communication in insects
Jul 2020, phys.org

Biomimetic artificial pheromone signaling in robotic swarms:
One of the most promising systems developed so far is COSΦ, a system that uses light to emulate pheromone release in humans and animals.

So far, the researchers evaluated their artificial pheromone system in a series of experiments in which a swarm of small mobile robots moved around and adapted to different environmental factors. Their results were highly promising, as their system enabled effective communication and prompted the desired group behaviors among members of the swarm.
via the University of Manchester: Seongin Na et al. Bio-inspired artificial pheromone system for swarm robotics applications, Adaptive Behavior (2020). DOI: 10.1177/1059712320918936


Researchers find a chemical that makes locusts swarm
Aug 2020, Ars Technica

Distant future, we will also have pheromone programming or engineering, so that we don't "swarm" and so we can be more easily controlled

via the Chinese Academy of Sciences: 4-Vinylanisole is an aggregation pheromone in locusts
Xiaojiao Guo. Nature volume 584, pages584–588(2020). 12 Aug 2020. DOI: 10.1038/s41586-020-2610-4
https://www.nature.com/articles/s41586-020-2610-4


Researchers one step closer to bomb-sniffing cyborg locusts
Aug 2020, phys.org

An irresistible scent makes locusts swarm, study finds
Aug 2020, phys.org

'The Smellicopter,' an obstacle-avoiding drone that uses a live moth antenna to seek out smells
Dec 2020, phys.org

Awesome. Made me think of the catcopter though. Ah, old times.
"Nature really blows our human-made odor sensors out of the water," said lead author Melanie Anderson, a UW doctoral student in mechanical engineering. "By using an actual moth antenna ...
via the University of Washington: Melanie Joyce Anderson et al. A bio-hybrid odor-guided autonomous palm-sized air vehicle, Bioinspiration & Biomimetics (2020). DOI: 10.1088/1748-3190/abbd81
 

Friday, September 16, 2016

Microbial Turing Test

aka Do Eukaryotes Think?

I mean, what does it really mean to think? Don’t we associate thinking with active, purposeful, agency? I think; thinking isn’t something that happens to me. Or is it? Sometimes I wonder if anything we do has intent, if anything we do is of our own volition. When we move through a room, are we moving, or is the room moving us?

Do we wear earrings, or are the earrings wearing us (à la Kevin Kelly’s What Technology Wants, he asks if the earrings are actually using us to spread the wearing of earrings by others; I wear them, you think I look cool, and then you go ahead and wear them too, and so on, and so on).

Further afield, if we do not think the way we think we think (pardon me), then can we say the reverse – that other things thought not to-think are in fact thinking? What does a very simple multicellular organism do? Does it run decision making algorithms? Here’s a piece from the end of Hidden Scents in the chapter called “Olfactory Space and n-Dimensionality” where we’re talking about what space is, what dimensionality is, and what it means for us to be in it and moving through it. The thing is, our olfactory sense is more tied up with our sense of space than any other. In some ways, it is the thing that moves us, it is the same part of our brain that activates motion, or motility, as it is called in simpler organisms. Little cellular buggers do something called chemotaxis, where they follow a chemical gradient in their environment. As those critters evolve, they become more and more liberated from their chemical environment; they can decide whether they want to follow the gradient or not. This transition from reaction to decision, from being a slave to one’s environment, to somewhat of a master, is the story of the development of our own mind. And our sense of smell is a vestige of this ancient part of us. (And to call back to the original question here, once this organism is ‘liberated’ from its environment by its ability to decide, then does the decision-making system now control it? Does the decision-making system have its own rules and limitations which influence the liberated organism in way the physical environment used to?)

Snippets from Hidden Scents
The eukaryote reacts to the chemical information it encounters in at least two ways – positive or negative. Humans are no different, swimming in a soup of information. Cognition aside (or does the eukaryote think?), we navigate even the complexities of our world in this most primary way. Every piece of information we receive is placed on this hedonic gradient and weighed in light of all the rest until the moment we initiate an action. The eukaryote does not move of its own accord but, instead, in response to the things outside it. It needs these things in order to move. Ultimately, it does not move itself; they move it. For the chemosensing organism, space is not a void to be traversed. Space is a distribution of the potentiality for movement. The distance between things is not important: There is no distance, only contact.