Getting Old Stinks

World’s first – We developed technology to prevent “Nonenal” (component for a body odor in older people)

Shiseido successfully developed completely new technology that prevents body odor in the middle-aged and old people through joint research with Takasago International Corporation. Now we are in the aging society, more people are bothered by “body odor unique to middle-aged and old people”. Shiseido focused on the change in the body odor caused by aging and discovered “nonenal” which is an odor component that is found in many middle-aged and older people and the level of which increases with age. -source: Shiseido

Although, this isn’t the first time this has hit the news:

It Stinks: The Smell of Aging: Japanese researcher's discovery that older men emit a pungent body odor hit a nerve with the populace. Now companies have jumped in with products to mask the offending scent. July 14, 1999. Mark Magnier, Los Angeles Times.

“Shoji Nakamura, whose million-dollar nose is reputedly able to distinguish among some 2,000 different odors, says he first noticed a distinctive smell among middle-aged and older men in 1987 and spent the next decade thinking about it.

"I'm very interested in body odor," he says.

“Now, after painstaking research, Shiseido has acted on Nakamura's evident insight. This September, the company will unveil what it says is the world's first product line of shampoos, powders and air fresheners designed to block, cover and otherwise obscure the unique smell of growing old.”

-source: latimes

Perhaps I belabor this point, but once again I can’t resist. There is something quite different between the skin of Asians and that of Caucasians. White people have more body odor, because they have more of the glands that produce body odor hiding under their skin.

Aside, they also smell like cheese, according to the Vietnamese soldiers who could sniff them out of the jungle. They also smell “like wet dogs,” according to Google’s predictive search algorithm circa 2014 – you can no longer test this; the script must’ve changed; personally I think it was a very typical semantic conflation between wet dog, which is a very specific smell, and wet hot dogs, which actually has something to do with cheese, or at least I’m willing to bet. I’m not an expert here, only an enthusiast.

And to complete the run, the first result for “why do ____ people smell like” went like this:

Why do white people smell like wet dog?

Why do black people smell like crayons?

Why don’t Asian people smell? (I swear, it would rearrange your question to produce this)

And when it came to ‘Indian people,’ the question would get so rearranged that it just isn’t worth adding it to the list. Again, the scripts have changed since, and in 2017 there is no way in hell Google would allow that to happen. Sorry, wish I screenshotted that little piece of anthropological gold.

Back to the point; I bring this up about Asian people having less body odor because it makes it seem more obvious that a Japanese man would be trying to quell old-people odor and not simply (armpit) body odor. Anyway, thanks Shiseido, for reminding me of my inevitable end.

[After some further research]
Then again, in total contrary, check out this study by  Johan Lundstrom, a neuropsychologist at the Monell Chemical Senses Center in Philadelphia (Monell is one of the premier institutes for olfactory research). They had a whole bunch of people put handkerchiefs under their arms overnight, and then, after cutting-up and mixing the samples of similar people, they put the smell samples in corresponding jars for willing participants to investigate.

Conclusion: "It turned out that the underarm odor of 75-to-95-year-olds was judged to be less intense and far more pleasant than the scent of either young or middle-aged adults. The most intense — and perhaps not coincidentally, the most unpleasant — odor came from 45-to-55-year-old men. Women in that age group, on the other hand, produced the most pleasant smell of everyone who wore the underarm pads.

"On the whole, men generally smelled worse than women, but that distinction disappeared in old age, the researchers found.

"As you grow older, you smell more and more like a woman," Lundstrom said. That is due to changes in men's hormone levels as they age. "It's almost as if you're going back to what happened before puberty." source: latimes

Anyway, totally to the contrary of the things mentioned via Shiseido. But, kind of reinforcing the Asian body odor/Asian smell scientist theory.

-image source: Shiseido

POST SCRIPT

More Old Folks Stuff –

Old Folks Jokes

Limbic Signal, 2016

Instant Grandpa

Limbic Signal, 2016

But Are You Sure You're Sure

Look carefully and tell me, what is this? Because it’s not what you think it is.

L’ange Du Foyeur, Max Ernst, 1937. Image source

Only because Hidden Scents presupposes that we are in the Age of Approximation do we pay attention to talk about certainty in science. The language of smell is anything but certain, and should make us second-guess what it means to “be sure” of something.  

Certainty in complex scientific research an unachievable goal

Feb 2017, phys.org

Looking at 41,000 measurements of 3,200 quantities - from the mass of an electron to the carbon dating of a sample - Bailey found that anomalous observations happened up to 100,000 times more often than expected.

"The chance of large differences does not fall off exponentially as you'd expect in a normal bell curve," said Bailey.

...

"The study shows that researchers in many fields do a good job of estimating the size of typical errors in their measurements, but usually underestimate the chance of large errors," said Bailey, noting that the larger-than-expected frequency of large differences may be an almost inevitable consequence of the complex nature of scientific research.

"As measurements become more and more accurate, the smallest things matter more and more," Bailey said.

...

"These insights can be beneficial given the inherently complex nature of scientific research," says Bailey. "But the chance of avoiding being wrong in some way on some level is almost impossible."

Embryos Can Smell Too

Comparing the embryonic development of various animals, Ernst Haeckel's Art Forms in Nature                   

Among the myriad ways olfaction is set apart from all other senses, this is perhaps the most important – Smell is the first sense to develop in ontogeny (the ‘lifetime’ of an organism), and begins in the womb.

We know babies can hear in the womb, but it isn’t often considered that they can smell too. Smell is a form of chemosensation. And if we think of an embryo as floating in a chemical soup, it makes sense that such an organism would be able to sense its surroundings. Possibly more surprising than this, it should be noted that adult humans have olfactory receptors in other parts of their bodes besides the nose. Certain organs are populated by the same nerve cells that relay the presence of aromatic molecules to our thinking brains via olfactory perception.

Here we must distinguish between sensation and perception. It is a misnomer to say that an embryo, or any such simple organism, can smell. Can you see with your eyes closed? Well, yes, but it depends on what you mean. The photoreceptors in your eyes still work whether your eyes are open or closed. In fact, they never stop working. The “seeing” part of you may stop, but the receptors are on all that time, ready to be stimulated by the most gentle of photon showers. (And when there is none – they make things up!) Babies in utero too can sense light levels in this way – but is that “seeing”? Not so much. And is it the same with smelling? Sort of. Perception requires a brain, but to sense does not. Plants can smell. Not really though; they can only sense chemicals.

Back through the mirror again, what does it mean for adult humans to smell, to perceive chemical signals? It is not a cognitive sense, or should we say a ‘cortical sense’. Smell is different in the way it uses a cortex, the perceptual-processor that creates an experience in our minds. For smell, the ‘processor’ is the limbic system itself, a beta-brain that runs inside, underneath, or within our more advanced human brains. This limbic system-chemical signal interaction is much more akin to the way a plant “sees” a sunset than a human. And so, to say that an embryo can smell, is less of a stretch than to say that it can see.

It makes matters more complex, however, when the chemical environment of the organism in utero actually affects its adult behavior. But because smell is a learned perception – an emergence of episodic memory – the osmic sensorium that we experience today and ultimately the way we respond to it, is predicated upon the very primitive origins of our ontological journey.

Post-Script

Study shows embryos can learn

phys.org, Dec 2014

Pond snails are able to sense chemicals released by their predators whilst they are still embryos in the egg and alter their behaviour accordingly, according to new research at Aberystwyth University and the University of Exeter and Plymouth University

When snails are exposed to predator smell during this very early developmental stage, they are better able to avoid predatory fish once they hatch...

The ability to respond to potential predators while still in the egg may be extremely important in allowing young vulnerable snails to survive.

Music, Maps, and Categorgonzola

Screenshot from Genealogy and History of Popular Music Genres from Origin till Present (1870-2016)

(highlighting my own personal favorite genre-neighborhood, the drum n bass part of town)

A Dizzying Infographic Traipses Through 146 Years of Music

WIRED, June 2016

A polymathic Belgian architect named Kwinten Crauwels has created a map worthy of praise for anyone who stays up at night thinking about how to articulate vast networks of cultural products.

The Music Map is an “interactive infographic that maps the definitions, relationships, and sub-genres of the last 146 years of pop music.

 It’s formally called “Genealogy and History of Popular Music Genres from Origin till Present (1870-2016)” and it’s creator certainly echoes my own struggles to organize the language of smell:

“You can never create the ultimate genre map—there is no such thing, because it’s a sociological reality, not a scientific one,” Crauwels says. “But you can at least create a very good approximation, so people can learn more.” He’s right; Crauwels has built a chart that’s actually chart-worthy.

-quotes taken from WIRED

POST SCRIPT

On Vague Notions of Accuracy

-About the confusion matrix, a great starting point for anyone who is trying to organize things, but is ultimately doomed to failure.

Network Address, 2013

You Are Never Gonna Bereave This

‘the sickly sweet smell of rotting flesh’-scented bodywash

Researchers isolate the ‘human smell of death’

Clarification: Scientists are not looking for the “smell of death”, but for the unique profile of molecules specific to decomposing humans when compared to other similar animals.

First of all – who cares? Forensic anthropologists care, because they want to help find dead human bodies in places populated by so many other dead critters. The wildfires in California are an example. With so many dead things there, how do we find the humans? Dogs can be trained (just like people, let Avery Gilbert give you a mouthful on that note) to recognize trace amounts of one particular chemical, or a signature profile, regardless of whether it is part of a much larger bouquet. If we could find the difference between dead human bodies and others, we could better inform our search.

Second thing – what’s the difference between “the smell of death” and the ‘human smell of death’ used in the headline above? Not much. This is certain because we already know “the smell of death”, and it’s called Cadaverine.

It’s got a lot to do with Putrescine, which is another part of “the smell of death” (as well as the smell of semen). Unfortunately, or fortunately, I cannot smell it; I’m anosmic; so I can’t be trusted. I’ll continue nonetheless. Cadaverine is described as the sickly sweet smell of rotting flesh, and you probably smell it more than you think (Exit 14 on the New Jersey Turnpike anyone?). How I wonder what dead bodies “really” smell like, because I am noseblind to one of its major constituents, but I will tell you this: On a midsummer afternoon, at a formal event like a wedding or church, where everyone is freshly-showered yet wafting personal microbiome clouds in competition with their carefully-crafted fragrance-enhancing products, Cadaverine trickles through the air.

Yes, a sheen of it covers these warm bodies, a fine layer of pulverized, rotting flesh, spread to every square inch by perhaps day-, perhaps week-old washcloths. I call it “dirty washcloth”, but I’d rather not. Sometimes, or in a strange animalistic way, it can actually smells good.

Oh, would you look at that, the Bvlgari Soir that’s been sitting on a test-strip on my desk for the past six days has been almost all dissipated, through the stages from complex aroma, to base notes, to one particular note, something musky, to this now lone Cadaverine. Even your cologne smells like dead people.

Post Script:

The Search for a Volatile Human Specific Marker in the Decomposition Process

Abstract

In this study, a validated method using a thermal desorber combined with a gas chromatograph coupled to mass spectrometry was used to identify the volatile organic compounds released during decomposition of 6 human and 26 animal remains in a laboratory environment during a period of 6 months. 452 compounds were identified. Among them a human specific marker was sought using principle component analysis. We found a combination of 8 compounds (ethyl propionate, propyl propionate, propyl butyrate, ethyl pentanoate, pyridine, diethyl disulfide, methyl(methylthio)ethyl disulfide and 3-methylthio-1-propanol) that led to the distinction of human and pig remains from other animal remains. Furthermore, it was possible to separate the pig remains from human remains based on 5 esters (3-methylbutyl pentanoate, 3-methylbutyl 3-methylbutyrate, 3-methylbutyl 2-methylbutyrate, butyl pentanoate and propyl hexanoate). Further research in the field with full bodies has to corroborate these results and search for one or more human specific markers. These markers would allow a more efficiently training of cadaver dogs or portable detection devices could be developed.

Rosier E, Loix S, Develter W, Van de Voorde W, Tytgat J, Cuypers E (2015) The Search for a Volatile Human Specific Marker in the Decomposition Process. PLoS ONE 10(9): e0137341. DOI: 10.1371/journal.pone.0137341

Post Post Script:

Sensory Psychologist Avery Gilbert features the “I Smell Dead People” installments on his blog First Nerve.

At the Limits of Rhino Punk

Today while reading fictional stories about the ethical implications of body modifications, I came across this passage about a man “being kept alive by the very technologies whose spiritual purpose he had so despised.”

How could his loved ones elect to replace a pulpy mess with the mere fleshy simulacrum of a nose, when rhinoplastic alternatives are available that will not only replace but upgrade the usual functioning of the sense organ?

-taken from The Modification of Eugene Berenger, Gregory Norminton/afterword Dr. Nihal Engin Vrana

I am all for speculative fiction. In fact, it was in part the imaginative meanderings stimulated by such fictions that led me to investigate the sense of smell in the first place, and mostly because its future is so unforeseeable.

This 2013 collection, titled Bio-Punk: Stories from the Far Side of Research, even takes the extra step to have scientists and ethicists write forewords for each of the stories. But upon this particular idea, I must ask – How would we upgrade such an organ? How would we modify not the cosmetic aspect but the sensory function itself?

Being that we do not fully understand the way the olfactory bulb converts aromatic molecules into meaningful electric signals, such an upgrade sounds nice, but the details of its operation are currently quite nebulous.

The only thing I can think of is to replace the epithelium patch with a vastly larger and invaginated one, like that of a dog’s. But immediately, I recall the adage of sensory psychologist and smell expert Avery Gilbert: If humans still walked on all fours sniffing each other’s butts, then we wouldn’t find dogs to be such exceptional noses.

And then, on second thought I ask – Is this even an improvement?

The trajectory of human development seems to be one of losing our sense of smell, or at least not paying as much attention to it anymore. In that case, an upgrade would be the wrong word. “Liberation from the beastly reekings of your meatbody!” reads the sign outside the local body-mod shop.

Bacteria At Work

Just a nice picture of a cell doing its job, image source

All this talk about artificial intelligence and robots taking our jobs? What about the lowly bacteria? It doesn’t sound as hi-tech as a car-building robot or a cashier-bot; in fact, it’s the opposite of hi-tech, isn’t it? These bacteria can do work previously limited to complicated industrial processes. The key thing here is replicating metabolic processes of plants to produce chemicals that are really hard to make artificially, or synthetically. What goes on inside a plant is sometimes magic to us (you know, the whole thing about light-into-energy aka photosynthesis), but this is an example where that magical process has been decrypted, and for commercial gain.

Instead of taking (rare and expensive) chemical A and putting it through a bevy of chemical reactions where it until it turns into (even more rare and expensive) chemical B, these folks have figured out how to use a different starting chemical, a much cheaper and more ubiquitous chemical, and to turn it to the same desired end product, minus the complex, expensive and time-consuming industrial processes.

What this means for the flavor and fragrance industry is that some ingredients which heretofore have been prohibitively expensive will now be way more accessible on the market.

Engineered bacteria produce rare and commercially useful compounds in large quantities

Feb 2017, phys.org

Using advanced fermentation technology, industrial biotech startup Manus Bio hopes to make manufacturing flavors, fragrances, and other products greener and more cost-effective—and maybe create new products in the process.

The MIT spinout has created a low-cost process for engineering microbes with complex metabolic pathways borrowed from plants, which can produce an array of rare and expensive ingredients used to manufacture noncaloric beverages, perfumes, toothpastes, detergents, pesticides, and even therapeutics, among other products.

...

Manus' commercial fermentation process involves engineering microbes with plant metabolic pathways, and placing them into large-scale fermentors with inexpensive sugars to feed on. While fermenting, the microbes produce large amounts of the ingredients that can be extracted with commercial processes. Manus plans to scale up to commercial levels this year and sell the products to their industrial partners.